Chronic: In 2-year gavage studies, there was clear evidence of carcinogenic activity of d-limonene for male rats, as shown by increased incidences of tubular cell hyperplasia, adenomas, and adenocarcinomas of the kidney. There was NO evidence of carcinogenic activity of d-limonene for female rats, for male mice, or for female mice. Not hazardous Label Elements GHS-US Labeling Hazard Pictograms (GHS) : None. Signal Word (GHS) : None Hazard Statements (GHS) : None Precautionary Statements (GHS) : P262: Do not get in eyes, on skin or on clothing. P305 + P351: IF IN EYES: Rinse with water for several minutes. Repeat if needed. P302 + P352: IF ON SKIN: Wash with plenty of soap and water.